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High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
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[Ma2 antibody and multiple mononeuropathies]

X Ayrignac1, G Castelnovo, E Landrault

  • 1Service de neurologie, CHU de Nîmes, 30029 Nîmes cedex, France.

Revue Neurologique
|June 21, 2008
PubMed

Insights

Anti-Ma2 antibodies, linked to brain and tumor proteins, are associated with paraneoplastic syndromes. This case highlights their connection to sensory-motor neuropathy in a patient with non-small-cell lung cancer.

Area of Science:

  • Neuroimmunology
  • Oncology

Background:

  • Onconeuronal antibodies, including Anti-Ma2, target proteins in the nervous system and tumors.
  • These antibodies are typically associated with limbic encephalitis and other paraneoplastic neurological syndromes.

Observation:

  • A case study of a 73-year-old woman with non-small-cell lung cancer is presented.
  • The patient exhibited a sensory and motor neuropathy.

Findings:

  • The patient was found to have Anti-Ma2 antibodies.
  • This indicates a potential association between Anti-Ma2 antibodies, non-small-cell lung cancer, and peripheral neuropathy.

Implications:

  • This case expands the known clinical spectrum associated with Anti-Ma2 antibodies.
  • It underscores the importance of considering onconeuronal antibodies in patients with unexplained neurological deficits and cancer.

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