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Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Related Experiment Video

Updated: Jul 4, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Clinical trials: past, present, and future.

William A Gray¹

¹Cardiovascular Research Foundation, Columbia University Medical Center, New York, NY 10032, USA. wgray@crf.org

Seminars in Vascular Surgery

|June 21, 2008

Summary

This summary is machine-generated.

Carotid stenting has evolved over 15 years. While effective for high-risk patients, its role in standard-risk patients with carotid stenosis requires further clarification through ongoing trials.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

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Last Updated: Jul 4, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Area of Science:

Interventional Neurology
Vascular Surgery
Medical Device Technology

Background:

Carotid stenting has undergone significant development over the last 15 years.
Early challenges included a lack of specialized equipment for the procedure.

Observation:

Pivotal trials focused on high-risk patients for surgical endarterectomy, utilizing dedicated stent technology and embolic protection filters.
These trials demonstrated favorable outcomes compared to surgical interventions.

Findings:

The US Food and Drug Administration has approved at least six carotid stent systems.
European randomized trials in standard surgical risk patients yielded mixed results, creating uncertainty about the technology's place in managing carotid stenosis.
Ongoing US trials aim to further define the role of carotid stenting in standard surgical risk patients, irrespective of symptom status.

Implications:

Carotid stenting is an established option for high-risk patients with carotid stenosis.
Further research is crucial to solidify the evidence base for carotid stenting in standard surgical risk populations.
The findings will refine treatment guidelines for carotid artery disease management.