Related Experiment Video

Updated: Jul 4, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Abnormal glucose regulation in an Australian acute coronary syndrome population: a prospective study

Sharon Chih1, Brendan M McQuillan, Joey Kaye

  • 1Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Australia. s.chih@victorchang.edu.au

Diabetes Research and Clinical Practice
|June 21, 2008
PubMed

Insights

Abnormal glucose regulation (AGR) is prevalent in acute coronary syndrome (ACS) patients, often undiagnosed. Oral glucose tolerance tests (OGTT) significantly improve AGR detection in this high-risk population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Abnormal glucose regulation (AGR) is a frequent and detrimental risk factor for patients experiencing acute coronary syndromes (ACS).
  • Early identification and management of AGR are crucial for improving outcomes in ACS patients.

Purpose of the Study:

  • To determine the prevalence of AGR in patients with ACS.
  • To assess the effectiveness of oral glucose tolerance tests (OGTT) in detecting AGR in this population.

Main Methods:

  • Prospective evaluation of 300 ACS patients.
  • Measurements included fasting blood glucose (BGL), glycated haemoglobin (HbA1c), and urinary albumin creatinine ratio (ACR).
  • Patients without diagnosed diabetes underwent OGTT at least 4 weeks post-discharge.

Main Results:

  • AGR was detected in 60% of patients on admission (32% diabetes, 28% impaired fasting glucose [IFG]).
  • OGTT identified new diabetes in 5%, impaired glucose tolerance (IGT) in 24%, and IFG in 6% of patients.
  • AGR was detected by OGTT in 25% of patients with normal admission BGL and in 50% of those with admission IFG.

Conclusions:

  • The majority of ACS patients exhibit AGR, with up to half remaining unrecognized.
  • OGTT is a valuable tool for enhancing the detection of AGR in ACS patients.
  • Identifying and managing AGR in ACS patients is essential for risk reduction.
Abstract

More Related Videos

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood06:28

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood

Published on: August 12, 2016

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...