Related Experiment Video
Updated: Jul 4, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group
Christopher Altgassen1, Hermann Hertel, Antje Brandstädt
1Department of Gynecology and Gynecologic Oncology, Universitätsmedizin Berlin, Charité, Hindenburgdamm 30, D-12203 Berlin, Germany. achim.schneider@charite.de
Purpose:
Single-institution case series have demonstrated the feasibility of the sentinel concept in cervical cancer. However, the diagnostic accuracy remains to be validated. We evaluated detection rate and diagnostic accuracy to predict the histopathologic pelvic nodal status in patients with cervical cancer of all stages.
Patients And Methods:
In a hypothesis-based, prospective, multicenter cohort study, patients underwent lymph node detection after labeling with technetium, patent blue, or both. After systematic pelvic and, if indicated, para-aortic node dissection, all lymph nodes were histopathologically examined. Detection rate, sensitivity, and negative predictive value (NPV) were calculated.
Results:
According to the protocol, 590 patients were eligible. Detection rate of pelvic sentinel nodes was 88.6% (95% CI, 85.8% to 91.1%) and was significantly higher for the combination of technetium and patent blue (93.5%; 95% CI, 90.3% to 96.0%). Of 106 patients with pelvic lymph node metastases, 82 had pelvic sentinel node metastases. The overall sensitivity was 77.4% (95% CI, 68.2% to 85.0%), which was lower than 90%, the predefined noninferiority margin (P < .001). Sensitivity in women with tumors
Conclusion:
In our cohort (all stages), sensitivity of the sentinel concept was low. However, patients with tumor diameter
