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Published on: August 23, 2019
L-myc gene polymorphism and risk of thyroid cancer
I Yaylim-Eraltan1, N Bozkurt, A Ergen
1Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul Research and Education Hospital, Surgery Clinic, Istanbul, Turkey.
Unlabelled:
L-myc gene polymorphism is a representative genetic trait responsible for an individual's susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism.
Aim:
To analyze the distribution of L-myc gene polymorphism in Turkish patients with thyroid disorders and thyroid cancers.
Methods:
We used a molecular genotyping method, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). We studied 138 patients of whom 47 had multinodular goiter, 13 had follicular cancer and 69 had papillar cancer, in comparison with control group of 109 healthy individuals.
Results:
No significant difference in the distribution of genotypes was observed between thyroid patients and controls. Carrying SS or LS genotype revealed a 1.96-fold (95% CI 0.573-6.706) risk for the occurrence of follicular cancer when compared with controls, and 3.11-fold (95% CI 0.952-10.216), when compared with multinodular goiter patients (p=0.04).
Conclusion:
We suggest that L-myc genotype profiling together with other susceptibility factors, may be useful in the screening for thyroid nodular malignancy.
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