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Introductory Analysis and Validation of CUT&RUN Sequencing Data
Published on: December 13, 2024
Computational tools for the analysis of rearrangements in mammalian genomes
Guillaume Bourque1, Glenn Tesler
1Genome Institute of Singapore, Singapore, Republic of Singapore.
Abstract:
The chromosomes of mammalian genomes exhibit reasonably high levels of similarity that can be used to study small-scale sequence variations. A different approach is to study the evolutionary history of rearrangements in entire genomes based on the analysis of gene or segment orders. This chapter describes three computational tools (GRIMM-Synteny, GRIMM, and MGR) that can be used separately or in succession to contrast different organisms at the genome-level to exploit large-scale rearrangements as a phylogenetic character.
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