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Related Concept Videos

Alveoli and Alveolar Ducts01:26

Alveoli and Alveolar Ducts

The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...

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A Mouse Distraction Osteogenesis Model
04:24

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Published on: November 14, 2018

Microvascular soft tissue changes in alveolar distraction osteogenesis.

Jerome A Lindeboom1, Keshen R Mathura, Dan M J Milstein

  • 1Department of Physiology and Oral Surgery, Academic Medical Center and Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands. j.a.lindeboom@amc.uva.nl

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|June 24, 2008
PubMed
Summary

Distraction osteogenesis significantly impacts oral mucosa vascularity, with increased capillary density observed primarily during the activation phase. This vascular response returns to baseline levels by the consolidation phase.

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Area of Science:

  • Oral surgery
  • Regenerative medicine
  • Vascular biology

Background:

  • Distraction osteogenesis is a surgical technique used to augment bone volume.
  • Understanding the vascular response is crucial for optimizing bone regeneration.
  • Previous studies have not fully quantified microvascular changes during oral mucosal distraction osteogenesis.

Purpose of the Study:

  • To quantify the effect of distraction osteogenesis on vascular density in human oral mucosa.
  • To compare microvascular changes between distracted and non-distracted sites.

Main Methods:

  • Alveolar distraction performed in 10 patients with alveolar ridge deficiencies.
  • Microvascular imaging using orthogonal polarization spectral imaging.
  • Assessment of capillary density changes from day 1 post-op through consolidation.

Main Results:

  • A bilateral decrease in capillary density was observed immediately post-surgery.
  • Capillary density significantly increased during the activation phase of distraction osteogenesis.
  • Vascularity returned to preoperative levels by the consolidation phase, with no significant differences between distracted and non-distracted sites.

Conclusions:

  • The primary increase in vascular response during distraction osteogenesis occurs during the activation phase.
  • This finding highlights the dynamic nature of vascular adaptation to mechanical stimuli in bone regeneration.