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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
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Surface nanocrystallization of hydroxyapatite coating.

Yu-Peng Lu1, Yan-Mei Chen, Shi-Tong Li

  • 1School of Materials Science and Engineering, Shandong University, Ji'nan 250061, China. Biosdu@sdu.edu.cn

Acta Biomaterialia
|June 24, 2008
PubMed
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Post-heat treatment creates nanocrystals on hydroxyapatite (HA) coatings, improving osteoblast response. Surface nanocrystallization is controllable and enhances cell attachment for biomaterial applications.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Engineering

Background:

  • Nano-featured biomaterials influence cell responses.
  • Hydroxyapatite (HA) coatings are used in bone regeneration.
  • Surface nanocrystallization of HA coatings is achievable via post-heat treatment.

Purpose of the Study:

  • To investigate the formation and control of surface nanocrystals on HA coatings.
  • To evaluate the effect of surface nanocrystallization on osteoblast response.

Main Methods:

  • Plasma-sprayed HA coatings were subjected to post-heat treatment at 650°C.
  • Varying holding times and repetitive treatments were applied to control nanocrystal formation.
  • Cell experiments were conducted using rat calvarial osteoblasts.

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Main Results:

  • Formation of 20-30nm nanocrystals on HA coatings after heat treatment.
  • Increased holding time led to more nanocrystals and aggregation.
  • Repetitive heat treatments resulted in hard aggregation, indicating controllable nanocrystallization.
  • Post-heat treated HA coatings showed significantly better osteoblast response compared to as-sprayed coatings.
  • Osteoblasts exhibited good attachment and filopodial interaction with the nanocrystallized surfaces.

Conclusions:

  • Surface nanocrystallization of HA coatings is a controllable process.
  • The nanocrystalline surface structure enhances osteoblast response and cell attachment.
  • Surface nanocrystallization should be considered in HA coating fabrication using post-heat treatment.