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Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Bilateral xanthogranulomatous pyelonephritis.

Kun-Hung Tsai¹, Ming-Yu Lai, Shu-Huei Shen

¹Division of Nephrology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA

|June 24, 2008

Summary

Xanthogranulomatous pyelonephritis is a rare kidney disease. This case report details a unique presentation and management of bilateral diffuse xanthogranulomatous pyelonephritis, avoiding nephrectomy.

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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

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Area of Science:

Nephrology
Pathology
Infectious Diseases

Background:

Xanthogranulomatous pyelonephritis (XGP) is a rare, chronic bacterial infection of the kidney.
It involves renal parenchyma destruction by granulomas and lipid-laden macrophages (foam cells).

Observation:

This case report describes a patient with bilateral diffuse XGP exhibiting subtle symptoms.
The patient did not present with typical signs like fever, flank pain, or urinary tract infection.

Findings:

The subtle presentation led to prolonged supportive care for 18 months instead of immediate bilateral nephrectomy.
This approach preserved residual renal function, avoiding the need for hemodialysis.

Implications:

Highlights the importance of considering atypical presentations of XGP.
Suggests conservative management may be viable in select cases to preserve renal function.
Emphasizes the potential risks of aggressive surgical intervention in bilateral diffuse XGP.