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Updated: Jul 4, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
Treatment of myasthenia gravis by preventing acetylcholine receptor modulation
Mario Losen1, Pilar Martínez-Martínez, Marko Phernambucq
1Neuroimmunology Group, Department of Neuroscience, Institute of Mental Health and Neuroscience, University of Maastricht, the Netherlands. m.losen@np.unimaas.nl
Abstract:
Myasthenia gravis (MG) is an autoimmune disease caused by antibodies mainly directed to the acetylcholine receptor (AChR) of the neuromuscular junction. Induction of antigenic modulation and complement activation by such autoantibodies leads to ultrastructural damage of the postsynaptic membrane and loss of AChR and associated proteins. Reduction of antigenic modulation by increasing the expression of the receptor-associated anchor protein, rapsyn, or by functionally monovalent competing IgG4 anti-AChR antibodies was shown to prevent MG disease activity. We propose that preventing antigenic modulation can be used as a treatment strategy for MG.
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