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Chemoselective modification of proteins: hitting the target
1Department of Chemistry, Stony Brook University, 1 John S. Toll Road, Stony Brook, NY 11790-3400, USA. isaac.carrico@sunysb.edu
Chemical Society Reviews
|June 24, 2008
Summary
Chemical biology uses synthetic molecules for precise, covalent modification of biomolecules. This review covers recent strategies for polypeptide tailoring in both in vitro and in vivo applications.
Area of Science:
- Chemical Biology
- Synthetic Chemistry
- Biochemistry
Background:
- Synthetic molecules are crucial for modulating and tracking biological events.
- Precise, covalent modification of biomolecules is a key objective in chemical biology.
- Existing strategies allow tailoring of polypeptides using endogenous residues or introduced functionality.
Purpose of the Study:
- To review recent advances in precise polypeptide modification.
- To discuss strategies for in vitro and in vivo applications.
- To provide insights into the field of chemical biology for researchers.
Main Methods:
- Literature review of recent advancements in polypeptide modification.
- Analysis of strategies utilizing endogenous residues.
- Analysis of strategies utilizing introduced functionality.
Main Results:
- Several strategies have emerged for specific polypeptide tailoring.
- These strategies are applicable in both in vitro and in vivo settings.
- Recent advances offer enhanced control over biomolecular modification.
Conclusions:
- Precise covalent modification of biomolecules is achievable through various synthetic strategies.
- These methods are vital for advancing chemical biology research.
- The discussed techniques have broad applications in biological studies.
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