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Updated: Jul 4, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Exploring refinements in targeted behavioral medicine intervention to advance public health
Abby C King1, David F Ahn, Audie A Atienza
1Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. king@stanford.edu
Background:
Similar to other fields, a targeted behavioral medicine perspective can aid decision-making related to participant-intervention matching.
Purpose:
To present one potentially useful definition of intervention targeting activity; describe potential targeting domains of particular relevance to behavioral medicine; discuss different statistical approaches to aid the targeted intervention development process; and discuss the challenges and opportunities accompanying the incorporation of targeted intervention development methods into behavioral randomized clinical trial (RCT) research.
Methods:
Drawing from recent conceptual work by the MacArthur group and other scientists in the field, methods and approaches to undertaking moderator analysis are discussed.
Results:
Examples of moderator analyses are provided which reflect the different statistical methods and variable domains that may serve as moderators of intervention success.
Conclusions:
The recommended exploratory work can help to make the most efficient use of RCTs to identify the best paths for subsequent RCT development in a resource-constrained era.
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