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Viability Assay of Trichoderma stromaticum Conidia Inside Human Peripheral Blood Mononuclear-Derived Macrophages
Published on: October 20, 2023
Update on the genus Trichosporon.
Thomas C Chagas-Neto1, Guilherme M Chaves, Arnaldo L Colombo
1Division of Infectious Diseases, Universidade Federal de São Paulo, Rua Diogo de Faria 822, 04037-002 Sao Paulo, Brazil.
Mycopathologia
|June 24, 2008
Summary
Trichosporon fungi, once rare pathogens causing white piedra, are now significant causes of invasive infections. Limited data exists on their susceptibility to new antifungal drugs, hindering effective treatment.
Area of Science:
- Mycology
- Infectious Diseases
- Medical Microbiology
Background:
- Trichosporon spp. are ubiquitous fungi found in nature and human microbiota.
- Historically, Trichosporon beigelii was known for causing white piedra; however, invasive infections are increasingly reported.
- The genus is now recognized as the second leading cause of disseminated yeast infections.
Purpose of the Study:
- To review the current understanding of Trichosporon infections, including taxonomy, clinical significance, and antifungal susceptibility.
- To highlight the challenges in species identification and standardized in vitro testing for Trichosporon spp.
- To underscore the need for more research into the efficacy of novel antifungal agents against these emerging pathogens.
Main Methods:
- Literature review of studies on Trichosporon spp. and trichosporonosis.
- Analysis of taxonomic changes based on molecular data.
- Examination of available in vitro susceptibility data for Trichosporon spp. against various antifungal compounds.
Main Results:
- The taxonomy of Trichosporon has been revised, with T. beigelii replaced by multiple species.
- Trichosporon infections are increasingly refractory to conventional antifungal therapies.
- There is a scarcity of in vitro susceptibility data for Trichosporon spp. against newer antifungal agents.
Conclusions:
- Accurate species identification and standardized in vitro susceptibility testing are crucial for managing trichosporonosis.
- Further research is needed to evaluate the effectiveness of novel antifungal drugs against emerging Trichosporon infections.
- Improved diagnostic and therapeutic strategies are essential to combat the growing threat of invasive trichosporonosis.
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