Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Variations in mass transfer to single endothelial cells.

Mark A Van Doormaal1, Ji Zhang, Shigeo Wada

  • 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.

Biomechanics and Modeling in Mechanobiology
|June 24, 2008
PubMed
Summary

Vascular endothelial cell topography has minimal impact on average mass transfer rates, despite variations across individual cells. This suggests cell surface shape is physiologically insignificant for mass transfer in atherogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Segmental Outflow and Trabecular Meshwork Stiffness in an Ocular Hypertensive Mouse Model.

Investigative ophthalmology & visual science·2026
Same author

Microtubule stability modulates Schlemm's canal cell mechanobiology and outflow facility in glaucoma.

bioRxiv : the preprint server for biology·2026
Same author

Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model.

bioRxiv : the preprint server for biology·2026
Same author

Author Response: Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.

Investigative ophthalmology & visual science·2026
Same author

Endothelial cell stiffness and type drive the formation of biomechanically induced transcellular pores.

Cell reports·2025
Same author

Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.

Investigative ophthalmology & visual science·2025

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cell Biology

Background:

  • Mass transfer between blood and arterial mural cells is crucial for atherogenesis.
  • Endothelial cell surface topography influences mass transfer patterns.

Purpose of the Study:

  • To investigate the relationship between endothelial cell surface topography and cellular mass transfer.
  • To determine the physiological significance of endothelial cell topography on mass transfer.

Main Methods:

  • Cultured porcine endothelial monolayers under shear and static conditions.
  • Measured cell topography using atomic force microscopy.
  • Calculated flow and concentration fields using finite element methods.

Main Results:

More Related Videos

Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies
12:28

Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies

Published on: June 3, 2021

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Related Experiment Videos

Last Updated: Jul 4, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies
12:28

Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies

Published on: June 3, 2021

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

  • Mass transfer varied significantly across individual cells, peaking at the nucleus.
  • Average mass transfer rates were similar to predictions for flat surfaces.
  • Cell height influenced mass transfer, but elongation due to shear stress did not.

Conclusions:

  • Endothelial cell topography has little effect on average mass transfer rates.
  • The impact of topography on mass transfer is likely physiologically insignificant compared to other hemodynamic factors.