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Updated: Jul 4, 2026

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Muscle compromise in diabetes.

F Yildirim Donmez¹, F Feldman

¹Department of Radiology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Acta Radiologica (Stockholm, Sweden : 1987)

|June 24, 2008

Summary

Diabetic muscle compromise, including infarction and myositis, is detectable with advanced imaging. Magnetic resonance imaging (MRI) aids early diagnosis and treatment of these muscle pathologies.

Area of Science:

Radiology
Musculoskeletal Imaging
Medical Diagnostics

Background:

Diabetes mellitus can lead to various muscle complications, including infarction, myositis, pyomyositis, and abscess formation.
These muscle conditions share similarities with those seen in trauma, alcoholism, neoplasia, vasculopathy, HIV infection, immunocompromised states, and hemoglobinopathies.
Recent advancements in imaging technology facilitate earlier detection and treatment of these muscle pathologies.

Purpose of the Study:

To outline the diagnostic features of diabetic muscle compromise using magnetic resonance imaging (MRI).
To differentiate between various muscle pathologies like infarction, myositis, pyomyositis, and abscesses based on imaging findings.
To emphasize the importance of accurate diagnosis for appropriate patient management.

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Main Methods:

Review of diagnostic modalities for soft-tissue pathologies, with a focus on MRI.
Description of characteristic MRI findings (T1- and T2-weighted images, contrast enhancement) for different muscle conditions.
Comparison of imaging features to distinguish between muscle infarction, myositis, pyomyositis, and abscesses.

Main Results:

Muscle infarction presents with acute edema, peripheral postcontrast enhancement, and central non-enhancing necrotic areas, lacking fluid collections.
Abscesses are typically characterized by the presence of focal fluid collections.
Early pyomyositis shows ill-defined muscle enlargement and T2 hyperintensity; myositis exhibits diffuse T2 hyperintensity with minimal or no enhancement.

Conclusions:

Magnetic resonance imaging (MRI) is crucial for diagnosing muscle compromise in diabetic patients.
Distinct imaging patterns allow differentiation between muscle infarction, myositis, pyomyositis, and abscesses.
Accurate recognition of these muscle pathologies is vital for tailoring patient management strategies.