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Updated: Jul 4, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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Current trends in hormone replacement therapy: perceptions and usage.

M H Birkhäuser¹, I Reinecke

¹Universitats-Frauenklinik Inselspital, Berne, Switzerland.

Climacteric : the Journal of the International Menopause Society

|June 24, 2008

Summary

This summary is machine-generated.

Physicians maintain confidence in hormone replacement therapy (HRT) for menopause symptoms, despite negative media coverage. Most believe HRT benefits outweigh risks, emphasizing lower doses for optimal outcomes.

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Area of Science:

Reproductive Medicine
Endocrinology
Menopause Management

Background:

Negative media interpretation of landmark studies, such as the Women's Health Initiative (WHI), has raised questions about hormone replacement therapy (HRT) safety and efficacy.
Physicians' confidence in prescribing HRT for menopausal symptoms may have been impacted by this media coverage.

Purpose of the Study:

To assess the impact of negative media coverage on physicians' confidence in using HRT for climacteric symptoms.
To evaluate current physician perspectives on HRT benefits, risks, and optimal dosing strategies.

Main Methods:

A structured online questionnaire was administered to 600 European and US gynecologists, obstetrician/gynecologists, and general practitioners experienced in climacteric symptom management.
The survey assessed awareness of recent HRT recommendations and physician confidence in HRT's risk-benefit profile.

Main Results:

98% of physicians agree menopause impacts quality of life, and 97% observe positive patient benefits from HRT.
90% believe HRT benefits outweigh risks in suitable patients, with 78% deeming negative media coverage unjustified.
While awareness of low-dose estrogen is high (82%), 67% emphasize lowering progestogen dose importance.

Conclusions:

Physicians in Europe and the US retain confidence in HRT for menopausal symptom management.
There is a consensus on optimizing HRT by lowering doses, particularly progestogen, to enhance the risk-benefit profile.
Continued education is needed to reinforce the role of lower progestogen doses in HRT therapy.