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Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells

Chantal Séguin1, Md Ruhul Abid, Katherine C Spokes

  • 1Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. seguin@muhc. mcgill.ca

Endothelium : Journal of Endothelial Cell Research
|June 24, 2008
PubMed
Summary

Thrombin reduces thrombomodulin (TM) expression and activity in endothelial cells. This suggests a positive feedback loop where coagulation activation may suppress anticoagulant protein C activation.

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