Related Experiment Video
Updated: Jul 4, 2026
07:39
Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
Placental pathology in trap sequence: clinical and pathogenetic implications
Thora S Steffensen1, Enid Gilbert-Barness, William Spellacy
1Department of Pathology, University of South Florida and Tampa General Hospital, Tampa, Florida, USA.
Fetal and Pediatric Pathology
|June 24, 2008
Summary
Twin reversed arterial perfusion sequence (TRAP) involves an acardiac twin. This case study reveals placental thrombotic vasculopathy in the donor twin
Area of Science:
- Reproductive Medicine
- Pathology
- Genetics
Background:
- Twin reversed arterial perfusion (TRAP) sequence is a rare complication in monochorionic pregnancies.
- It necessitates arterial-arterial and venous-venous anastomoses between twins, leading to circulatory failure in the acardiac twin.
Observation:
- This study details a case of monochorionic monozygotic twins with TRAP sequence and an acardiac twin.
- Key placental findings included villous immaturity, significant calcifications, and extensive fetal thrombotic vasculopathy.
Findings:
- The placenta exhibited thrombotic vasculopathy in the donor twin's umbilical vein and chorionic plate vessels.
- Unlike previous reports, thrombi were observed in the donor twin's umbilical vessels and chorionic plate veins.
Implications:
- These findings suggest a potential role for thrombotic events in the donor twin.
- Further research is needed to correlate these clinicopathological findings and understand their impact on TRAP sequence etiology and donor twin outcomes.
Related Concept Videos
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:25Urinary Tract Infection II: Pathophysiology
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...