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alpha-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn
Muhammad Arif Lodhi1, M Iqbal Choudhary, Abdul Malik
1Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi-75270, Pakistan.
Journal of Enzyme Inhibition and Medicinal Chemistry
|June 24, 2008
Abstract:
The lignans (1-8) isolated from the roots of Vitex negundo Linn. were screened against the serine proteases alpha-chymotrypsin, thrombin and prolyl endopeptidase. Compounds 3 and 4 were found to be active only against alpha-chymotrypsin and were noncompetitive and competitive inhibitors of the enzyme, respectively. Ki values were found to be in the range 31.75-47.11 microM.