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Changes in bladder function in the one year spontaneously diabetic BB rat.

P A Longhurst1, R M Levin

  • 1Division of Urology, University of Pennsylvania School of Medicine, Philadelphia 19104.

The Journal of Urology
|August 1, 1991
PubMed
Summary
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Spontaneously diabetic rats showed altered micturition and bladder function one year after diabetes onset. Insulin treatment in diabetic rats may offer some protective effects on bladder contractility.

Area of Science:

  • Urology
  • Endocrinology
  • Physiology

Background:

  • Diabetes mellitus can affect multiple organ systems, including the urinary tract.
  • Understanding long-term diabetic complications in bladder function is crucial for patient management.

Purpose of the Study:

  • To investigate micturition characteristics and in vitro urinary bladder function in insulin-treated diabetic rats one year after diabetes onset.
  • To compare bladder function in diabetic rats with age-matched non-diabetic controls.

Main Methods:

  • Assessment of micturition parameters (frequency, volume) in diabetic and control rats.
  • In vitro analysis of urinary bladder strip contractility in response to various stimuli (nerve stimulation, carbachol, phenylephrine, ATP, KCl).
  • Correction of contractile data for bladder tissue mass differences.

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Main Results:

  • Diabetic rats exhibited increased water intake, urine output, micturition frequency, and urine volume per micturition.
  • Bladder body mass was significantly increased in diabetic rats.
  • While absolute contractile responses were similar, normalized responses of bladder body strips to carbachol, ATP, and KCl were decreased in diabetic rats.
  • No significant differences in bladder base strip contractility were observed between groups.

Conclusions:

  • One year of diabetes in BB rats leads to significant, slow-developing changes in micturition and bladder function.
  • These changes are qualitatively similar to, but quantitatively less severe than, those in streptozotocin-induced diabetes, likely due to insulin treatment.
  • Insulin therapy may have a partially ameliorative effect on diabetic bladder dysfunction.