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Nodular scleritis following alendronate therapy.

Khalid F Tabbara1

  • 1Eye Center and the Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia. k.tabbara@nesma.net.sa

Ocular Immunology and Inflammation
|June 24, 2008
PubMed
Summary

Alendronate sodium, a medication for osteoporosis, can cause nodular scleritis, an eye inflammation. This condition recurred in a patient upon re-exposure to the drug, highlighting a potential adverse effect.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Background:

  • Alendronate sodium is a bisphosphonate commonly prescribed for osteoporosis.
  • Ocular side effects of bisphosphonates are rare but have been reported.

Observation:

  • A 54-year-old male developed inferonasal nodular scleritis eight weeks after initiating alendronate sodium.
  • Clinical examination revealed ocular inflammation, with laboratory work-up being inconclusive.

Findings:

  • The patient experienced complete resolution of scleritis after subtenon's triamcinolone acetate injection.
  • Recurrence of nodular scleritis was observed two weeks after rechallenge with alendronate sodium.

Implications:

  • This case suggests a potential causal link between alendronate sodium and nodular scleritis.
  • Rechallenge with alendronate sodium confirmed its role in the recurrence of scleritis, indicating a possible drug-induced ocular inflammatory response.

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