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Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS). A double-blind, randomized study
Rickard Ekesbo1, Peter M Nilsson, Kristina Sjölund
1Primary Health Care Centre, Dalby, Sweden. rickard.ekesbo@skane.se
Objective:
To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS).
Design:
A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study.
Subjects:
Eighty-two patients with IBS were randomized to a diet with either SPC or placebo.
Main Outcome Measures:
The overall clinical condition and the quality of life were measured by VAS and SF-36 questionnaire, respectively. The plasma levels of ASF were determined in 14 patients with dominating loose stools before and after diet.
Results:
All patients significantly (p<0.001) improved in IBS-related symptoms irrespective of active or placebo diet. In an active-diet sub-group with diarrhoea (n=11) there was a significant (p<0.05) correlation between the increase of plasma ASF level and the improvement on the VAS.
Conclusion:
Both study groups improved significantly on the VAS but no additive effect was seen for the active treatment. In the sub-group with loose stools, the SPC diet induced ASF plasma levels in IBS patients and was correlated to significant symptom improvement in the individual patient.
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