[Recurrent intestinal ischemia due to factor VIII]
Jesús Javier Castellanos Monedero1, María Luisa Legaz Huidobro, María Angeles Galindo Andugar
1Servicio de Medicina Interna, Hospital La Mancha Centro, Alcázar de San Juan, Avenida de la Constitución 3, Ciudad Real, Spain. castellanosvela@hotmail.com
Gastroenterologia Y Hepatologia
|June 24, 2008
Summary
Recurrent intestinal ischemia in women can stem from small vessel thrombosis linked to factor VIII, a procoagulant factor. This case highlights a rare cause of bowel ischemia.
Area of Science:
- Gastroenterology
- Hematology
- Vascular Medicine
Background:
- Intestinal ischemia presents diagnostic challenges.
- Multiple etiologies contribute to bowel ischemia.
- Small vessel thrombosis is a potential cause.
Observation:
- A female patient experienced recurrent episodes of bowel ischemia.
- The ischemia was attributed to small vessel thrombosis.
- Factor VIII, a procoagulant factor, was identified as the underlying cause.
Findings:
- Factor VIII procoagulant activity can lead to thrombosis in small mesenteric vessels.
- This mechanism can manifest as recurrent intestinal ischemia.
- The case underscores a specific thrombophilia in the etiology of intestinal ischemia.
Implications:
- Early diagnosis of factor VIII-related thrombosis is crucial for managing recurrent intestinal ischemia.
- Understanding this specific etiology can guide therapeutic strategies.
- This case expands the differential diagnosis for unexplained bowel ischemia.
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