Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Composition and antimicrobial activity of the essential oil from the branches of Jacaranda cuspidifolia Mart. growing in Sichuan, China.

Natural product research·2017
Same author

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Nature·2017
Same author

SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.

Molecular and cellular endocrinology·2017
Same author

Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

Cancer discovery·2017
Same author

Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.

Biochemical pharmacology·2017
Same author

Safety and efficacy evaluation of pertuzumab in patients with solid tumors.

Medicine·2017
Same journal

Localized pH regulation via a dynamic proton-converting raft for gastroesophageal reflux disease.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Systems engineering of engineered live biotherapeutics: A discovery-to-translation framework for streamlining microbiome therapeutic development.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Endogenous-metabolite-inspired polyamine-oleic acid lipids for safe mRNA delivery and PCSK9 gene editing.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Tunable rigid spikes on virus-like porous silica enable mechanistically controlled nanovaccine platforms.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy.

Journal of controlled release : official journal of the Controlled Release Society·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Reverse polymeric micelles for pharmaceutical applications.

Marie-Christine Jones1, Hui Gao, Jean-Christophe Leroux

  • 1Canada Research Chair in Drug Delivery, Faculty of Pharmacy, University of Montreal, P.O. Box 6128, Downtown Station, Montreal, Quebec H3C3J7, Canada.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 24, 2008
PubMed
Summary
This summary is machine-generated.

Star-shaped polymers self-assemble into reverse micelles, effectively solubilizing hydrophilic molecules like peptides in organic media. This enables novel water-free formulations with prolonged drug delivery and enhanced therapeutic effects.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Pharmaceutical Technology

Background:

  • Poly(glycidyl methacrylate)s are synthesized via atom transfer radical polymerization.
  • Water-soluble poly(glycerol methacrylate)s (PG(OH)MAs) are derived from these precursors.
  • PG(OH)MAs are modified via esterification with long-chain acyl chlorides.

Purpose of the Study:

  • To investigate the self-assembly of alkylated PG(OH)MAs into reverse micelles (RMs).
  • To evaluate the capacity of these RMs for solubilizing hydrophilic solutes in organic media.
  • To explore the potential of RMs for developing novel drug delivery systems, particularly water-free peptide formulations.

Main Methods:

  • Synthesis of star-shaped and linear poly(glycidyl methacrylate)s using atom transfer radical polymerization.
  • Esterification of poly(glycerol methacrylate)s with acyl chlorides (C12-C18) to create alkylated derivatives.
  • Characterization of self-assembled reverse micelles (20-60 nm) in organic solvents/oils.
  • Assessment of dye extraction from aqueous to organic phases.
  • Encapsulation and in vitro/in vivo release studies of vasopressin.

Main Results:

  • Alkylated PG(OH)MAs self-assemble into nanosized reverse micelles (20-60 nm).
  • These RMs efficiently extract anionic dyes from water and solubilize them in organic phases.
  • Encapsulation of vasopressin in RMs improved its solubility in oil, enabling water-free formulations.
  • In vitro release showed slow diffusion (<15% in 7 days), accelerated by emulsification.
  • In vivo studies demonstrated prolonged vasopressin effect (>48 h) compared to aqueous solutions (8-10 h).

Conclusions:

  • Reverse micelles formed from alkylated PG(OH)MAs are effective solubilizers for hydrophilic compounds in organic media.
  • These RMs offer a promising platform for developing advanced pharmaceutical formulations, including water-free peptide delivery systems.
  • The prolonged in vivo efficacy highlights the potential of RMs in enhancing therapeutic outcomes through controlled release.