Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Alterations in Muscle Tone lll

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mycological Profile and Associated Factors Among Patients with Dermatophytosis in Astana, Kazakhstan.

Journal of fungi (Basel, Switzerland)·2025

Same author

p63 in primary cutaneous anaplastic large cell lymphoma.

International journal of dermatology·2024

Same author

Comparison of large language models in generating patient handouts for the dermatology clinic: A blinded study.

JAAD international·2024

Same author

Medical therapies for melasma.

Journal of cosmetic dermatology·2022

Same author

Psoriasis adverse events and associated medications as reported in the US Food and Drug Administration's Adverse Event Reporting System from 2016 to 2021.

JAAD international·2022

Same author

Virtual mentorship in dermatology.

International journal of dermatology·2022

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Amyopathic dermatomyositis resembling stasis dermatitis.

Anne M Seidler¹, Daniel I Wasserman, Aldo González-Serva

¹Department of Dermatology, Tufts University School of Medicine, Boston, Massachusetts, USA.

Journal of the American Academy of Dermatology

|June 24, 2008

Summary

Dermatomyositis can present unusually, mimicking venous stasis dermatitis. This case highlights the importance of considering paraneoplastic syndromes in ovarian cancer patients, even after chemotherapy.

Related Experiment Videos

Last Updated: Jul 4, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Area of Science:

Dermatology
Oncology
Internal Medicine

Background:

Dermatomyositis is an idiopathic inflammatory myopathy characterized by characteristic skin rashes and proximal muscle weakness.
Ovarian carcinoma is a common gynecologic malignancy with diverse clinical presentations.
Paraneoplastic syndromes can manifest with various dermatologic conditions in cancer patients.

Observation:

A patient with ovarian carcinoma developed a skin eruption resembling venous stasis-like dermatitis.
The rash onset occurred after chemotherapy administration, initially suggesting a drug-induced reaction.
The patient's underlying ovarian malignancy provided a crucial context for evaluating the skin findings.

Findings:

The unusual dermatitis presentation in the context of ovarian cancer suggested a paraneoplastic process.
Dermatomyositis was considered as a potential manifestation of the underlying malignancy.
The temporal relationship with chemotherapy prompted consideration of drug-induced etiology alongside the paraneoplastic possibility.

Implications:

This case underscores the need to consider paraneoplastic dermatomyositis in patients with ovarian carcinoma presenting with atypical skin manifestations.
Dermatologists and oncologists should be aware of the diverse cutaneous presentations of paraneoplastic syndromes.
Early recognition of paraneoplastic processes can aid in timely cancer diagnosis and management, potentially improving patient outcomes.