Related Experiment Video
Updated: Jul 4, 2026
03:48
Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis
Published on: March 1, 2024
Modulating effect of ginger extract on rats with ulcerative colitis.
Hanan S El-Abhar1, Lamiaa N A Hammad, Hala S Abdel Gawad
1Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Hanabhar@yahoo.com
Journal of Ethnopharmacology
|June 24, 2008
Summary
Ginger extract effectively reduced ulcerative colitis severity in rats, comparable to sulfasalazine. This study highlights ginger
Area of Science:
- Gastroenterology
- Pharmacology
- Natural Product Research
Background:
- Ginger rhizomes have a history of traditional use for gastrointestinal issues.
- Scientific evidence supports ginger's antioxidant and anti-inflammatory properties.
- Renewed interest exists in ginger for managing chronic inflammatory diseases.
Purpose of the Study:
- To investigate ginger extract's (GE) efficacy in mitigating ulcerative colitis (UC).
- To assess GE's role in modulating the severity of experimentally induced UC.
Main Methods:
- Rats were administered varying doses of GE or sulfasalazine before and after acetic acid-induced UC.
- Colonic mucosal injury was evaluated macroscopically and histologically.
- Redox state (MDA, PCO, GSH) and inflammatory markers (MPO, TNF-alpha, PGE2) were measured.
Main Results:
- Ginger extract treatment improved all measured parameters in rats with UC.
- GE's effects were comparable to sulfasalazine, particularly at higher doses.
- Histological and biochemical findings correlated with reduced colonic mucosal injury.
Conclusions:
- Ginger extract demonstrates significant therapeutic potential against acetic acid-induced ulcerative colitis.
- GE's beneficial effects are likely attributed to its antioxidant and anti-inflammatory mechanisms.
- These findings support ginger as a potential natural remedy for inflammatory bowel disease.
