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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
HIV-1 infected patients older than 50 years. PISCIS cohort study
G Navarro1, M M Nogueras, F Segura
1Corporación Sanitaria Parc Tauli, Sabadell, Barcelona, Spain. gnavarro@tauli.cat
The Journal of Infection
|June 24, 2008
Summary
Older adults diagnosed with HIV have distinct characteristics and a significant, though slower, immune recovery on antiretroviral therapy. Despite higher mortality, they demonstrate a good treatment response.
Area of Science:
- Infectious Diseases
- Gerontology
- Immunology
Background:
- The aging population with HIV presents unique clinical challenges.
- Understanding differences between older and younger HIV-infected individuals is crucial for tailored care.
Purpose of the Study:
- To characterize demographic, clinical, and immunological differences in older versus younger HIV-infected individuals.
- To assess treatment response and outcomes in these distinct age groups.
Main Methods:
- Prospective cohort study (PISCIS) of newly diagnosed, naive HIV patients.
- Comparison of two groups: G1 (>=50 years) and G2 (18-49 years).
- Statistical analyses included chi-squared, t-tests, Cox regression, and linear mixed models.
Main Results:
- Older adults (G1) were more likely male, had higher rates of sexual transmission and AIDS at diagnosis.
- Despite a higher initial viral load, both groups showed good viral suppression on HAART.
- G1 had lower CD4 counts but demonstrated a greater CD4 increase over time compared to G2.
- Mortality was higher in G1 (9%) than G2 (4%).
Conclusions:
- Older individuals diagnosed with HIV exhibit distinct epidemiological and clinical profiles.
- They show a robust viral and immunological response to highly active antiretroviral therapy (HAART).
- Age-specific considerations are important for managing HIV in older populations.
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