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Updated: Jul 4, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

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[Digital ischemia related to bromocriptin].

A Mekinian¹, X Kyndt, I Girard-Buttaz

¹Service de médecine interne et néphrologie, centre hospitalier de Valenciennes, Valenciennes, France.

La Revue De Medecine Interne

|June 24, 2008

Summary

Bromocriptine, used postpartum, can rarely cause digital ischemia and stroke. Discontinuing the drug led to a favorable outcome in a patient experiencing these rare vascular complications.

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Area of Science:

Neurology
Vascular Medicine
Pharmacology

Background:

Bromocriptine, a dopamine agonist, is prescribed for postpartum conditions.
Previous reports link bromocriptine to serious vascular events like stroke and myocardial infarction.

Observation:

A 28-year-old woman developed digital ischemia five days after starting bromocriptine.
Magnetic resonance imaging confirmed a stroke in the right posterior cerebellar artery.

Findings:

The patient's digital ischemia and stroke were associated with bromocriptine use.
Discontinuation of bromocriptine resulted in a favorable clinical course.

Implications:

This case highlights the potential for paradoxical vasoconstriction with bromocriptine.
Healthcare providers should monitor for rare vascular ischemic complications in patients using bromocriptine.