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Sinonasal neuroendocrine carcinoma: a case report
1Department of ENT Surgery, Queen's Hospital, Belvedere Rd., Burton-upon-Trent, Derby DE13 0RB, UK. dulanimendis@yahoo.com
Ear, Nose, & Throat Journal
|June 25, 2008
Summary
This case report details a rare sinonasal neuroendocrine carcinoma (NEC) in an elderly male. Successful surgical and radiation treatment led to no recurrence at 20 months.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Neuroendocrine carcinoma (NEC) is an uncommon malignancy.
- Sinonasal NEC presents diagnostic challenges due to its rarity and varied presentation.
Observation:
- A 73-year-old man presented with right nasal obstruction, discharge, and epistaxis.
- Examination revealed a bleeding, polypoid mass in the right nasal cavity.
- CT scan showed a lesion confined to the nasal cavity with adjacent sinus opacification.
Findings:
- Histologic evaluation confirmed invasive, poorly differentiated large-cell NEC.
- Differential diagnosis included high-grade olfactory neuroblastoma.
- The patient underwent lateral rhinotomy, medial maxillectomy, and adjuvant radiotherapy.
Implications:
- This case highlights the importance of considering NEC in sinonasal masses.
- Multimodal treatment (surgery and radiotherapy) can achieve favorable outcomes.
- Further research into sinonasal NEC is warranted.