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Updated: Jul 4, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Bioactive materials in endodontics.

Bénédicte Enkel¹, Cécile Dupas, Valérie Armengol

¹Nantes University Hospital, Pôle Odontologie, ERT 10-51 Equipe de Recherche Clinique en Odontologie et Chirurgie Osseuse, Faculté de Chirurgie Dentaire 1 Place Alexis Ricordeau, Nantes Cedex 01, France. benedicte.enkel@univ-nantes.fr

Expert Review of Medical Devices

|June 25, 2008

Summary

This summary is machine-generated.

New biomaterials show promise for endodontic treatment, offering biocompatible and bioactive alternatives to traditional root canal fillers. These advanced materials could improve treatment outcomes and enable new applications in regenerative dentistry.

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Accessing the Cytotoxicity and Cell Response to Biomaterials

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

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Published on: March 31, 2021

Area of Science:

Biomaterials Science
Endodontic Dentistry
Regenerative Medicine

Background:

Endodontic treatments frequently fail due to complex root canal anatomy and the use of potentially harmful filling materials.
Current root canal filling techniques face challenges in achieving complete obturation and long-term periapical tissue health.

Purpose of the Study:

To evaluate existing and novel biomaterials for endodontic applications.
To explore the potential of advanced biomaterials as root canal fillers, drug-delivery vehicles, and scaffolds for tissue engineering.

Main Methods:

Literature review of studies on biomaterials used in endodontics.
Evaluation of calcium hydroxide, mineral trioxide aggregate, calcium phosphate ceramics, and cements.
Focus on injectable bone substitutes and injectable calcium phosphate cements.

Main Results:

Traditional biomaterials like calcium hydroxide and mineral trioxide aggregate have limitations.
Injectable bone substitutes and calcium phosphate cements exhibit favorable biocompatibility, bioactivity, and rheological properties.
These novel materials present potential as advanced root canal fillers.

Conclusions:

Injectable calcium phosphate cements and bone substitutes are promising alternatives for endodontic filling materials.
These biomaterials offer potential for use as drug-delivery systems and scaffolds in pulp tissue engineering.
Further research into these advanced materials could significantly improve endodontic treatment success and regenerative capabilities.