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Microwave generated solid dispersions containing Ibuprofen.

Mariarosa Moneghini¹, Barbara Bellich, Pietro Baxa

¹Department of Pharmaceutical Sciences, University of Trieste, Trieste, Italy. moneghin@units.it

International Journal of Pharmaceutics

|June 25, 2008

Summary

Microwave irradiation efficiently prepared solvent-free solid dispersions of Ibuprofen (IBU) using hydrophilic carriers. This technique enhanced drug release, showing promise for novel drug delivery systems.

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Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Materials Science

Background:

Poorly soluble drugs present challenges in achieving effective therapeutic concentrations.
Developing advanced drug delivery systems is crucial for improving drug bioavailability.
Solid dispersions (SD) offer a strategy to enhance the solubility and dissolution rate of poorly soluble drugs.

Purpose of the Study:

To investigate microwave irradiation (MW) as a technique for preparing solvent-free solid dispersions (SD).
To formulate an enhanced release dosage form for Ibuprofen (IBU) using hydrophilic carriers.
To evaluate the physico-chemical characteristics and dissolution properties of microwave-prepared SD.

Main Methods:

Preparation of solid dispersions (SD) using microwave irradiation (MW) with Ibuprofen (IBU) and hydrophilic carriers (PVP/VA 64, HP-beta-CD).
Physico-chemical characterization of the prepared SD, physical mixtures, and IBU alone.
In vitro dissolution studies to compare the release profiles of different formulations.

Main Results:

Microwave irradiation produced solvent-free solid dispersions (SD) of Ibuprofen (IBU).
Physico-chemical characterization confirmed the amorphous state of IBU in the SD formulations.
The prepared SD exhibited a remarkable enhancement in the in vitro dissolution rate compared to physical mixtures and IBU alone.

Conclusions:

Microwave irradiation is a viable and attractive technique for preparing solvent-free solid dispersions (SD).
The amorphous form of IBU within the SD, facilitated by hydrophilic carriers, significantly improves drug dissolution.
This method offers a novel approach for developing advanced drug-polymer systems with enhanced drug release profiles.