Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemoproteomics unveils the antibacterial mechanism of silver ions: inhibiting peptidoglycan synthesis <i>via</i> targeting Mur family proteins in <i>Staphylococcus aureus</i>.

Chemical science·2026
Same author

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple-Negative Breast Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Programmable enhancement of endogenous mRNA translation through CRISPR-guided epitranscriptomic regulation.

Cell discovery·2026
Same author

Fexofenadine promotes bone formation and inhibits bone resorption via dual targeting of cPLA2 and Smad2.

International immunopharmacology·2026
Same author

A compact variable stiffness joint for compliant robotics enabled by torsion-spring mean-diameter variation.

Scientific reports·2026
Same author

High-Intensity Alternating Current Stimulation as an Add-On to Multidisciplinary Intensive Rehabilitation for Parkinson's Disease: A Randomized Controlled Trial.

CNS neuroscience & therapeutics·2026

Related Experiment Video

Updated: Jul 4, 2026

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Dual fluorescence/contactless conductivity detection for microfluidic chip.

Cui Liu1, Yun-yan Mo, Zuan-guang Chen

  • 1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510089, China.

Analytica Chimica Acta
|June 25, 2008
PubMed
Summary
This summary is machine-generated.

A novel dual detection system integrates fluorescence and contactless conductivity detectors on a microfluidic chip for simultaneous analysis. This compact, portable system enhances sample characterization for both fluorescent and charged analytes.

More Related Videos

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Related Experiment Videos

Last Updated: Jul 4, 2026

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Instrumentation

Background:

  • Microfluidic devices offer miniaturization and efficiency for chemical analysis.
  • Simultaneous detection of diverse analytes often requires multiple detectors, increasing system complexity.
  • Integrating multiple detection modes onto a single chip can enhance analytical capabilities.

Purpose of the Study:

  • To develop and evaluate a novel dual detection system combining fluorescence detection (FD) and contactless conductivity detection (CCD) on a single microfluidic chip.
  • To achieve simultaneous detection of both fluorescent and charged analytes at a common position.
  • To optimize the system's performance and assess its detection limits for various analytes.

Main Methods:

  • Integration of a fluorescence detector (using a blue LED and photodiode) and a contactless conductivity detector on a microfluidic chip.
  • Simultaneous operation of both detectors at a shared detection zone within a single separation channel.
  • Optimization of detection conditions for the dual system.
  • Performance evaluation using inorganic ions (K+, Na+) and fluorescent molecules (fluorescein sodium, FITC, FITC-labeled amino acids).

Main Results:

  • Successful integration and simultaneous operation of FD and CCD on a microfluidic chip.
  • Demonstrated enhanced detection characterization by combining fluorescence and conductivity information.
  • Achieved low limits of detection for FD (e.g., 0.02 µmol/L for fluorescein sodium) and CCD (e.g., 0.58 µmol/L for K+).
  • The system effectively detected both fluorescent and charged analytes.

Conclusions:

  • The developed dual detection system provides a compact, portable, and efficient platform for simultaneous analysis of fluorescent and charged species.
  • This integrated approach enhances analytical capabilities compared to single-detector systems.
  • The system shows promise for various applications requiring multi-modal detection in microfluidic formats.