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Published on: January 26, 2024
Lymph node micrometastasis in node negative early gastric cancer
1Department of Surgery, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Republic of Korea.
Summary
The incidence of lymph node micrometastasis in node-negative early gastric cancer (EGC) was 10%. Lymphatic invasion and larger tumor size were identified as independent risk factors for micrometastasis in EGC patients.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Pathology
Background:
- The clinical significance of lymph node micrometastasis in node-negative gastric cancer requires further elucidation.
- Early gastric cancer (EGC) staging is critical for treatment decisions and prognosis.
Purpose of the Study:
- To assess the incidence of lymph node micrometastasis in node-negative EGC.
- To identify independent risk factors associated with lymph node micrometastasis in EGC.
Main Methods:
- Utilized anticytokeratin immunohistochemical staining to detect micrometastasis.
- Investigated 90 patients with node-negative EGC who underwent curative resection (1991-2000).
- Analyzed 3526 lymph nodes for micrometastatic deposits.
Main Results:
- Identified micrometastasis in 10% of patients (9 out of 90).
- Micrometastasis incidence was significantly higher with lymphatic invasion (p=0.012), venous invasion (p=0.026), and larger tumor size (p=0.003).
- Independent risk factors for micrometastasis were lymphatic invasion (RR=22.915) and tumor size (RR=1.493).
Conclusions:
- The incidence of lymph node micrometastasis in node-negative EGC is 10%.
- Lymphatic invasion and tumor size are significant independent risk factors for lymph node micrometastasis in EGC.
- These findings aid in risk stratification for node-negative EGC patients.
