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Published on: April 25, 2014
Angina at 1 year after myocardial infarction: prevalence and associated findings
Thomas M Maddox1, Kimberly J Reid, John A Spertus
1Cardiology Section (111B), Denver Veterans Affairs MedicalCenter, 1055 Clermont St, Denver, CO 80209, USA. thomas.maddox@va.gov
Insights
Angina affects nearly 20% of patients one year after myocardial infarction (MI). Modifiable factors like continued smoking and depression increase the risk of post-MI angina.
Area of Science:
- Cardiology
- Clinical Medicine
- Public Health
Background:
- Angina management is crucial post-myocardial infarction (MI).
- Prevalence and predictors of one-year post-MI angina remain largely unknown.
- Understanding these factors is key to improving patient outcomes.
Purpose of the Study:
- To determine the prevalence of angina one year after myocardial infarction (MI).
- To identify sociodemographic, clinical, and treatment-related factors associated with one-year post-MI angina.
Main Methods:
- A multicenter cohort study involving 2498 patients hospitalized for acute MI.
- Angina assessment using the Seattle Angina Questionnaire one year post-MI.
- Multivariate regression analysis to identify associated factors.
Main Results:
- 19.9% of patients reported angina one year post-MI.
- Younger age, nonwhite male sex, prior angina, prior coronary artery bypass graft (CABG) surgery, and recurrent rest angina during hospitalization were associated with one-year angina.
- Continued smoking, post-discharge revascularization (PCI or CABG), and significant depressive symptoms (new, persistent, or transient) were also associated with one-year angina.
Conclusions:
- Angina is prevalent one year after myocardial infarction, affecting nearly one in five patients.
- Key modifiable factors associated with one-year angina include persistent smoking and depressive symptoms.
- These findings highlight potential targets for intervention to improve long-term angina management post-MI.
Background:
Eradication of angina is a primary goal of care after myocardial infarction (MI). However, the prevalence of angina 1 year after MI and factors associated with it are unknown.
Methods:
From January 1, 2003, through June 28, 2004, 2498 patients with acute MI were recruited from 19 hospitals in the United States. Among this multicenter cohort of patients, angina was measured by the Seattle Angina Questionnaire 1 year after hospitalization for MI. Multivariate regression modeling identified the sociodemographic factors, clinical history, MI presentation, inpatient treatments, and outpatient treatments associated with 1-year angina, adjusted for site.
Results:
Of 1957 patients in the cohort, 389 (19.9%) reported angina 1 year after MI. After multivariate analysis, patients with 1-year angina were more likely to be younger (relative risk [RR] per 10-year decrease, 1.19; 95% confidence interval [CI], 1.09-1.30), to be nonwhite males (RR, 1.50; 95% CI, 1.16-1.96), to have had prior angina (RR, 1.78; 95% CI, 1.54-2.06), to have undergone prior coronary artery bypass graft surgery (RR, 1.92; 95% CI, 1.51-2.44), and to experience recurrent rest angina during their hospitalization (RR, 1.54; 95% CI, 1.22-1.93). Among the outpatient variables, patients with 1-year angina were more likely to continue smoking (RR, 1.23; 95% CI, 1.02-1.48), to undergo revascularization after index hospitalization (percutaneous coronary intervention or coronary artery bypass graft) (RR, 1.37; 95% CI, 1.09-1.73), and to have significant new (RR, 1.96; 95% CI, 1.34-2.87), persistent (RR, 1.88; 95% CI, 1.29-2.75), or transient (RR, 1.77; 95% CI, 1.49-2.11) depressive symptoms.
Conclusions:
Angina occurs in nearly 1 of 5 patients 1 year after MI. It is associated with several modifiable factors, including persistent smoking and depressive symptoms.
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