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Chronic Helicobacter pylori infection is associated with peripheral arterial disease

Yasunori Sawayama1, Maki Hamada, Shigeru Otaguro

  • 1Department of General Medicine, Kyushu University Hospital, Hakata-ku, Fukuoka 812-8582, Japan. sawayama@genmedpr.med.kyushu-u.ac.jp

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|June 25, 2008
PubMed

Insights

Helicobacter pylori infection, a common cause of stomach issues, may be a risk factor for peripheral arterial disease (PAD). This study found a higher prevalence of H. pylori in PAD patients compared to controls.

Area of Science:

  • Vascular Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Helicobacter pylori (H. pylori) infection is epidemiologically and pathogenetically linked to coronary atherosclerosis.
  • The relationship between H. pylori infection and peripheral arterial disease (PAD) remains unclear.

Purpose of the Study:

  • To investigate the association between H. pylori infection and the presence of peripheral arterial disease (PAD).

Main Methods:

  • A case-control study comparing 69 PAD patients with 143 age-matched controls.
  • H. pylori infection diagnosed via IgG antibodies, (13)C-urea breath test, and histology.
  • Multiple logistic regression analysis used to assess risk factors.

Main Results:

  • The prevalence of H. pylori infection was significantly higher in PAD patients (79.7%) than in controls (44.8%).
  • Stepwise logistic regression identified H. pylori infection and hypertension as significant risk factors for PAD.
  • PAD patients were aged 50-92 years, with most in Fontaine grades I and II.

Conclusions:

  • Chronic H. pylori infection may be a contributing risk factor for the development of peripheral arterial disease (PAD).
  • Further research is warranted to elucidate the pathogenic mechanisms linking H. pylori to PAD.

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