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Structure-based design of Aurora A & B inhibitors

Anders Poulsen1, Anthony William, Angeline Lee

  • 1S*BIO Pte Ltd., 1 Science Park Road, #05-09 The Capricorn, Singapore Science Park II, 117 528, Singapore, Singapore. anders_poulsen@sbio.com

Journal of Computer-Aided Molecular Design
|June 25, 2008
PubMed
Summary

Researchers developed novel inhibitors targeting Aurora kinases, crucial for cell division and often overexpressed in cancer. Optimized compounds achieved nanomolar potency, with selective Aurora B inhibitors identified for potential oncology therapies.

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