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Published on: January 22, 2020
[Correlation between VEGF expression and clinical characteristic of patient with non-Hodgkin's lymphoma: an initial
Jiang Zhu1, Wei-Ya Wang, Ming Jiang
1Department of Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To study whether VEGF expression is associated with clinical characteristics such as gender, age, aggressive, stage, B-symptoms and complete remission (CR) rate of patients with non-Hodgkin's lymphoma.
Methods:
Expression of VEGF had been tested in 98 biopsy samples by immunohistochemical method as LSAB. Chi-Square test was used to do the statistical analysis of ratio comparison between different groups.
Results:
Comparing VEGF positive rates grouped by sexuality, age, aggressive grade or stage, the results suggested no significant correlation between them. VEGF positive rate of patients accompanied with B-symptoms was 86.1%, versus 51.6% of patients B-symptoms free, P = 0.001. Among 94 patients, their responses to chemotherapy could be estimated, delaminated by B-symptoms, and the CR rate of VEGF negative group was significantly higher, P values were 0.000 and 0.028.
Conclusions:
Expression of VEGF is associated with B-symptoms and poor response to chemotherapy in patients with non-Hodgkin's lymphoma, there was not any relationship to have been found between VEGF expression and sexuality, age, aggressive grade, stage.
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