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Updated: Jul 4, 2026
Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
[Research progress of neural stem cells signal transduction pathway]
Wenxian Zhang1, Yujun Wang, Xiaoyan Wang
1Department of Orthopedics, Traditional Chinese Medicine Hospital, Lanzhou Gansu, 730050, P.R. China. DOCzhangwx@126.com
Objective:
To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells.
Methods:
The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed.
Results:
The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways.
Conclusion:
At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear.
