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Updated: Aug 4, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
Published on: January 12, 2012
Intrastriatal dialysis evidence for a direct inhibitory effect of benztropine on dopamine re-uptake
1Department of Neuropsychopharmacology (Tsumura), Gunma University, School of Medicine, Japan.
Abstract:
A direct inhibitory effect of benztropine on dopamine (DA) reuptake in the striatum was established by in vivo microdialysis of anesthetized rats. Benztropine was infused by means of a microdialysis probe positioned stereotaxically in the striatum. Extracellular DA collected from dialysate was measured by high-performance liquid chromatography using an electrochemical detector. Benztropine was found to cause a dose-dependent inhibition of re-uptake of DA in the nerve terminal area of the dopaminergic system.
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