Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228
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Updated: Jul 4, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Jared R Mays1, José A Restituyo, Rebeccah J Katzenberger
1School of Pharmacy, University of Wisconsin, Madison, WI 53705.
Abstract:
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.
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