Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228

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Jared R Mays1, José A Restituyo, Rebeccah J Katzenberger

  • 1School of Pharmacy, University of Wisconsin, Madison, WI 53705.

Tetrahedron Letters
|June 26, 2008
PubMed

Abstract:

FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.

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