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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 4, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

[Current therapeutic options for liver metastasis].

Jorge Martínez C1, Nicolás Jarufe C, Robinson González D

  • 1Departamento de Cirugía Digestiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. jmartin@med.puc.cl

Revista Medica De Chile
|June 26, 2008
PubMed
Summary
This summary is machine-generated.

Advances in surgical and medical therapies have improved outcomes for liver metastasis, particularly from colorectal cancer. New treatments offer better survival rates and are being explored for other cancers as well.

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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
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Last Updated: Jul 4, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

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09:52

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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

Area of Science:

  • Hepatobiliary Malignancies
  • Surgical Oncology
  • Medical Oncology

Background:

  • The liver is a frequent site for hematogenous metastasis, especially from gastrointestinal cancers, often classified as stage IV disease.
  • Historically, treatment for liver metastasis was approached with skepticism, but recent decades have seen significant therapeutic advancements.

Purpose of the Study:

  • To summarize current therapeutic tools for liver metastasis, focusing on colorectal cancer.
  • To highlight the advantages and outcomes associated with various treatment modalities.
  • To discuss the potential for improved outcomes with multimodality approaches.

Main Methods:

  • Review of surgical and medical therapies for liver metastasis.
  • Analysis of outcomes for hepatic resections, chemotherapy infusion, ablation techniques, and targeted therapies.
  • Evaluation of treatment efficacy in colorectal cancer liver metastasis and other relevant malignancies.

Main Results:

  • Major hepatic resections are now feasible with low morbidity and mortality (<3%).
  • Colorectal cancer liver metastasis shows 5-year survival rates of 30% or more following advanced treatments.
  • New therapies include hepatic artery infusion, ablation (alcohol, cryo, radiofrequency), and novel systemic chemotherapy with targeted agents.

Conclusions:

  • Selected patients with liver metastasis, particularly from colorectal cancer, now have effective therapeutic options.
  • Emerging therapies are also benefiting patients with neuroendocrine tumors and other non-colorectal liver metastases.
  • Multimodality treatment strategies are expected to further enhance survival and outcomes for liver metastasis.