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Lipid abnormalities in black renal patients
D E Burrell1, A Antignani, P Goldwasser
1Long Island College Hospital, Avram Center for Kidney Disease, Brooklyn, NY 11201.
New York State Journal of Medicine
|May 1, 1991
Summary
Blacks generally exhibit better cardiovascular risk profiles than whites across various kidney disease stages, including lower total cholesterol and higher HDL-C. Longitudinal studies showed no significant impact of race on lipid profiles over time.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Clinical Biochemistry
Background:
- Racial disparities in lipoprotein (LP) and cardiovascular (CV) abnormalities are recognized in the general and dialysis populations.
- Limited research exists on race-LP-CV interactions within diverse renal disease groups.
Purpose of the Study:
- To investigate racial differences in lipid profiles and CV risk ratios across various chronic kidney disease (CKD) stages.
- To examine longitudinal changes in lipid profiles among end-stage renal disease (ESRD) patients and their relation to race.
Main Methods:
- Cross-sectional analysis of lipid profiles (total cholesterol, HDL-C, apo A-I, apo B) and risk ratios (TC/HDL-C, A-I/B) in patients with normal renal function, nephrotic syndrome, hemodialysis, peritoneal dialysis, post-transplant, and renal insufficiency.
- Longitudinal study of lipid profiles in ESRD patients over four yearly cross-sections, using ANOVA with covariate adjustment.
Main Results:
- Blacks generally showed a more favorable CV risk profile than whites, with lower total cholesterol, higher HDL-C, and better apo ratios across all renal disease groups.
- Whites had lower HDL-C and higher TC/HDL-C ratios than blacks in hemodialysis and CAPD populations.
- Longitudinal analysis revealed no significant effect of race on lipid profiles, though apo B decreased and A-I/B increased over two years.
Conclusions:
- Race is associated with distinct lipid profiles and cardiovascular risk factors across different stages of renal disease.
- While cross-sectional data suggest racial differences, longitudinal studies in ESRD patients did not demonstrate a significant impact of race on lipid profile changes over time.