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Chloroquine: novel uses & manifestations
1Division of Physiology, Faculty of Health, Birmingham City University, Birmingham, UK. rgcooperuk@yahoo.com
The Indian Journal of Medical Research
|June 26, 2008
Summary
Chloroquine (CHQ), an old antimalarial, shows promise for new uses due to its lysosomotropic and immunomodulatory effects. Despite side effects, CHQ may be reconsidered for treating viral infections, cancer, and potentially malaria.
Area of Science:
- Pharmacology
- Drug Repurposing
- Immunomodulation
Background:
- Chloroquine (CHQ) is a historically significant antimalarial drug.
- CHQ possesses lysosomotropic properties, leading to diverse therapeutic applications beyond malaria.
- Its physiological and systemic effects are well-documented.
Purpose of the Study:
- To review the history and pharmacology of chloroquine.
- To explore the biochemical and physiological mechanisms of CHQ.
- To present novel applications of CHQ in treating viral infections and cancer.
Main Methods:
- Literature review of chloroquine's history and pharmacology.
- Analysis of proposed biochemical and physiological mechanisms.
- Overview of emerging therapeutic uses.
Main Results:
- CHQ exhibits lysosomotropic and immunomodulatory properties.
- Novel applications in viral infections and cancer treatment are identified.
- CHQ's potential for reintroduction into malaria treatment is considered.
Conclusions:
- CHQ, despite toxicity, holds potential for future therapeutic uses.
- Lysosomotropic and immunomodulatory mechanisms underpin its novel applications.
- Revisiting CHQ for malaria treatment is a possibility.
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