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Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

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Whipple's disease: an endoscopic and histologic study.

Klaus Mönkemüller¹, Lucia C Fry, Ulrike von Arnim

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany. Klaus.Moenkemueller@med.ovgu.de

|June 26, 2008

Summary

Whipple's disease (WD) has diverse endoscopic findings, including mucosal changes and villi alterations. Esophagogastroduodenoscopy with biopsy is crucial for diagnosing gastrointestinal WD.

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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

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Published on: August 26, 2014

Area of Science:

Gastroenterology
Pathology

Background:

Whipple's disease (WD) frequently involves the gastrointestinal tract, yet its endoscopic presentation is poorly documented.
This study aimed to detail the endoscopic and pathological features of WD.

Observation:

Endoscopic findings in WD include mucosal edema, discoloration, erythema, subepithelial hemorrhages, and megaduodenum.
Magnification endoscopy revealed flattened villi, villi filled with white material, and internal white ring-like structures.

Findings:

Histologically, WD is characterized by foamy macrophages with coarse granular cytoplasm, strongly positive for periodic acid-Schiff (PAS).
A wide spectrum of endoscopic appearances was observed in patients with WD.

Implications:

Esophagogastroduodenoscopy with duodenal biopsies is an accurate diagnostic method for gastrointestinal WD.
Magnification endoscopy improves visualization of mucosal details, aiding in WD diagnosis.