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Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Tissue Injury: Inflammation and Repair

Tissue Injury: Inflammation and Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

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Related Experiment Video

Updated: Jul 4, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

[The wound healing stimulation].

O E Lutsevich, V G Shirinskiĭ, A B Shekhter

|June 26, 2008

Summary

This study found that using serotonin and/or nitric oxide (NO) therapy accelerates wound healing after abdominal surgery. This method reduces inflammation and promotes tissue repair, leading to faster recovery and fewer complications.

Area of Science:

Surgical innovation
Wound healing research
Pharmacological therapies

Background:

Postoperative wound healing following emergency abdominal surgery presents significant challenges.
Minimizing complications and accelerating recovery are critical for patient outcomes.

Purpose of the Study:

To develop and evaluate a method for stimulating postoperative wound healing.
Investigate the efficacy of serotonin and nitric oxide (NO) therapy in surgical wound management.

Main Methods:

Morphologic and morphometric analyses of surgical wounds.
Application of serotonin and/or NO-therapy in postoperative treatment.
Clinical evaluation in a cohort of 763 patients with laparotomic wounds.

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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Related Experiment Videos

Last Updated: Jul 4, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Main Results:

Serotonin and/or NO-therapy decreased distrophic and inflammatory processes.
Enhanced fibroblast proliferation, neoangiogenesis, and collagen production were observed.
Faster wound healing and a significant absence of infectious suppurative complications were demonstrated in treated patients.

Conclusions:

Serotonin and/or NO-therapy represent a promising method for enhancing postoperative wound healing.
The therapeutic approach effectively mitigates complications associated with laparotomic wounds.
This strategy offers a significant advancement in surgical recovery protocols.