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Updated: Jul 4, 2026
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
[Hormonal therapy in breast cancer]
J Espinós1, C Reyna, S de la Cruz
1Area de tumores ginecológicos y de mama, Departamento de Oncología, Clínica Universitaria, Facultad de Medicina. Universidad de Navarra, Pamploma. jespinos@unav.es
Revista De Medicina De La Universidad De Navarra
|June 27, 2008
Summary
Hormonal therapy is a cornerstone in breast cancer treatment. This review covers Tamoxifen, aromatase inhibitors, and Fulvestrant, aiding in selecting optimal drugs for patients.
Area of Science:
- Oncology
- Endocrinology
Context:
- Hormonal therapy has historically been the primary systemic treatment for breast cancer.
- Established options included Tamoxifen and ovarian suppression/ablation for early and advanced disease.
Purpose:
- To review available hormonal therapy options for breast cancer.
- To provide guidance on selecting the optimal drug based on patient-specific indications.
Summary:
- The introduction of aromatase inhibitors, novel selective estrogen receptor modulators (SERMs), and the anti-estrogen Fulvestrant represents significant progress in breast cancer treatment.
- These advancements, while beneficial, have increased the complexity of choosing the most effective therapy for individual patients.
Impact:
- Facilitates informed clinical decision-making in breast cancer hormonal therapy selection.
- Aims to optimize treatment outcomes by matching patients with the most suitable hormonal agents.
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