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Updated: Jul 4, 2026
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
[Venous ulcer--present view on aetiology, diagnostics and therapy]
T Toporcer1, L Lakyová, J Radonak
1II. Chirurgická klinika LF UPJS, Kosice, Slovenská republika. topyto@gmail.com
Casopis Lekaru Ceskych
|June 27, 2008
Summary
Chronic venous insufficiency causes most chronic wounds, leading to venous ulcers through inflammation and cell senescence. Treatment involves debridement, compression after ruling out arterial disease, and interdisciplinary care.
Area of Science:
- Vascular Medicine
- Dermatology
- Wound Healing Research
Context:
- Chronic venous insufficiency (CVI) is the primary cause of chronic wounds, affecting 5-8% of the population.
- Venous ulcers, a consequence of CVI, impact approximately 1% of individuals and are linked to chronic inflammation.
- Chronic inflammation in venous ulcers disrupts normal healing processes, leading to cellular senescence.
Purpose:
- To outline the etiology, diagnosis, and management of venous ulcers.
- To highlight the role of chronic inflammation and cellular senescence in venous ulcer pathogenesis.
- To discuss diagnostic tools and therapeutic strategies for venous ulcer management.
Summary:
- Venous ulcers stem from chronic venous insufficiency and inflammation, causing cellular senescence and impaired wound healing.
- Diagnosis relies on clinical presentation and supporting tests like duplex ultrasound and ankle brachial index.
- Treatment includes debridement, compression therapy (after excluding arterial disease), and adjuvant dressings, requiring an interdisciplinary approach.
Impact:
- Understanding the pathophysiology of venous ulcers aids in developing targeted therapeutic interventions.
- Early diagnosis and appropriate management, including compression therapy, can improve patient outcomes and reduce complications like malignant transformation.
- This comprehensive overview underscores the need for multidisciplinary collaboration in managing complex venous ulcer cases.
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