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Updated: Jul 4, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Published on: June 17, 2013
[Peripheral nerve injury and the degree of motor involvement in Parkinson's disease: a correlation study]
Z Chovancová1, P Kanovský, I Nestrasil
1Neurologická klinika LF UP a FN - Centrum pro diagnostiku a ldecu neurodegenerativních onemocnĕní, Olomouc. zuzana.chovancova@fnol.cz
Background:
The aim of the study was to validate a hypothesis about the presence of a concomitant peripheral nerves injury in patients suffering from neurodegenerative disorders. The study was focused on the correlation between motor involvement in Parkinson's disease and peripheral nerves injury.
Methods And Results:
23 patients suffering from Parkinson's disease, which was diagnosed in terms of strict UK-PDBB criteria, were examined. There were 14 men (mean age: 57 years, mean age at the disease onset: 51 years, mean disease duration: 7 years, mean duration of dopaminergic treatment: 4 years) and 9 women (mean age: 67 years, mean age at the disease onset: 63 years, mean duration of disease: 4 years, mean duration of dopaminergic treatment: 1 year). Polyneuropathy was clinically present and confirmed using EMG examination in 10 patients (43.5 %), 5 men and 5 women.
Conclusions:
Our observation indicates that the neurodegenerative process can be involved not only in the degeneration of central nervous system, but also in the peripheral disorders in this population.
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