Factitious thyrotoxicosis induced by mesotherapy: a case report.

Area of Science:

• Endocrinology
• Dermatology
• Cosmetic Science

Background:

• Mesotherapy involves cutaneous injections for cosmetic fat and cellulite reduction.
• Adverse events reported to date have been primarily local.
• This study investigates a rare systemic complication of mesotherapy.

Observation:

• A female patient developed thyrotoxicosis following cosmetic mesotherapy.
• The mesotherapy formulation contained triiodothyroacetic acid.
• Skin alterations including epidermal barrier disruption and vascular changes were noted.

Findings:

• The patient's thyrotoxicosis is attributed to systemic absorption of thyroid hormone metabolites from mesotherapy.
• Disturbances in type III deiodinase activity and fibroblast paracrine function may contribute.
• Co-injected vasoactive compounds might influence absorption and systemic effects.

Implications:

• This case represents the first report of factitious thyrotoxicosis induced by mesotherapy.
• Highlights the potential for systemic adverse effects from cosmetic mesotherapy.
• Raises awareness among practitioners and patients about risks associated with mesotherapy.