Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Goiter

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of portal vein embolisation uses in colorectal liver metastases: evidence from a rapid review.

BMJ open·2026

Same author

Mental health coping strategies and support needs among marginalised further and higher education students in the UK: A cross-sectional study.

PLOS mental health·2026

Same author

Epidemiology of Injury in Elite and Amateur Soccer Referees: A Systematic Review and Meta-analysis.

Sports medicine (Auckland, N.Z.)·2025

Same author

Corrigendum to "Exploring the factors contributing to increase in facility child births in Bangladesh between 2004 and 2017-2018" [Heliyon Volume 9, Issue 5, MAY 2023, Article e15875].

Heliyon·2025

Same author

Investigating time to first birth among women of reproductive age in Bangladesh: a survival analysis of nationwide cross-sectional survey data.

Journal of health, population, and nutrition·2024

Same author

How can UK public health initiatives support each other to improve the maintenance of physical activity? Evidence from a cross-sectional survey of runners who move from Couch-to-5k to parkrun.

Health promotion international·2023

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Acute blastomycosis thyroiditis.

Shiraz Moinuddin¹, Hassana Barazi, Mohammed Moinuddin

¹Department of Internal Medicine, George Washington University, Washington, District of Columbia, USA.

Thyroid : Official Journal of the American Thyroid Association

|June 27, 2008

Summary

This summary is machine-generated.

Fungal thyroiditis is rare, but this study documents the first case of acute blastomycosis infection of the thyroid. Early Itraconazole treatment showed a satisfactory response in a young woodcutter.

More Related Videos

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Related Experiment Videos

Last Updated: Jul 4, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Area of Science:

Mycology
Infectious Diseases
Endocrinology

Background:

Acute thyroiditis is uncommon, with fungal infections being exceptionally rare.
Cervical blastomycosis has previously been reported to mimic a thyroid mass.
This study focuses on a rare presentation of fungal infection within the thyroid gland.

Observation:

A 23-year-old woodcutter presented with symptoms suggestive of thyroid involvement.
The patient exhibited no overt signs or history of immunodeficiency.
Diagnostic imaging and biopsy confirmed the presence of blastomycosis in the thyroid.

Findings:

This case represents the first documented instance of acute blastomycosis of the thyroid.
Biopsy and imaging studies were crucial in confirming the diagnosis.
The patient showed a positive initial response to Itraconazole therapy.

Implications:

This finding expands the known clinical spectrum of blastomycosis.
Highlights the importance of considering rare fungal infections in thyroid pathology.
Suggests Itraconazole as a potential treatment for thyroidal blastomycosis.